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FBCM is currently considered to be the most common cause of vitamin B12 deficiency, caused by impairment in the release of the vitamin from food, commonly because of conditions such as gastritis, achlorhydria, gastrectomy, use of antacids, or proton pump inhibitors (PPIs), gastric atrophy in the elderly, and Helicobacter pylori infection (63, 74)

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To address these challenges, significant research efforts have been devoted to understanding the molecular mechanisms by which S